|
|
¼Õ´ë¿±³¼ö´Ô ¼¼¹Ì³ª°¡ ½ÄÇ°»ý¹°»ê¾÷¿¬±¸¼Ò ÁÖÃÖ·Î °³ÃֵǾú½À´Ï´Ù. ------------------------------------------------------------- ¿¬Á¦: ½ÄÇ°¾Ë·¯Áö¿Í GM½ÄÇ°ÀÇ ¾ÈÀü¼º ¿¬ÀÚ: ´ë±¸ÇÑÀÇ´ëÇб³ Çѹæ¹ÙÀÌ¿À½ÄÇ°Çаú ¼Õ´ë¿±³¼ö´Ô Àå¼Ò: ³ó»ý´ë 3È£°ü 225È£ °ÀÇ½Ç ------------------------------------------------------------------------------------------------------------- ¹ßÇ¥ÀÇ ¿äÁö´Â ´ÙÀ½°ú °°½À´Ï´Ù. 1. ¾Ë·¯ÁöÀÇ Á¾·ù---ÈíÀÔ¼º, Á¢Ã˼º, ¾à¹°, °ïÃæ, ¹°¸®Àû, ¸ð±â,,, 2. ½ÄÇ°¾Ë·¯Áö´Â ¾à 25% Á¤µµ. 3¼¼ÀÌÇÏ ¿µÀ¯¾ÆÀÇ °æ¿ì 6% Á¤µµ°¡ ½ÄÇ°¿¡ ´ëÇÑ ¾Ë·¯Áö DBPCFC¿¡ ÀÇÇÏ¸é ¼ºÀÎÀÇ ¾à 1.5% Á¤µµ 3. ¹ßº´ Áõ°¡ ¿øÀÎ---½Ç³»»ýÈ°, Èí¿¬, ¹è±â°¡½º, ½Å¼ÒÀç, À̹°Áú ÈíÀÔ, ¸é¿ªÃ¼°è ÀÌ»ó ¶Ç´Â °ú¹Î ¹ÝÀÀ 4. ¿ë¾î Á¤ÀÇ Adverse food reaction Food allergy---¸é¿ª°ÅºÎ ¹ÝÀÀ Food intolerance---½ÅüÀÇ ´ë»çº¯È¿¡ ÀÇÇÑ ºñ¸é¿ª¹ÝÀÀ 5. Áõ»ó---atopic dermatitis, eczema, rhinitis, asthma, urticaria(µÎµå·¹±â) 6. ¾Ë·¯Áö Áø´Ü¹ý---º´·Â ¹× ½ÄÇ°Àϱâ(history and diet diary) skin test(IgE ¹ÝÀÀ¼º Á¶»ç, À§¾ç¼º/À§À½¼º(30-40%) Á¦°Å½ÄÀÌ ¿ä¹ý °æ±¸À¯¹ß½ÃÇè(open challenge, single-blind challenge, double-blind placebo controlled food challenge; DBPCFC) ±âŸ---ÀڱؽÃÇè, ƯÀÌ IgE Ç×ü ½ÃÇè 7. allergenÀÇ Á¾·ù---egg white, milk, soybean, peach etc. 8. EpitopeÀÇ Á¾·ù---conformation epitope, sequence epitope 9. mast cell¿¡¼ IgEÀÇ epitope ÀÎ½Ä ±âÀü 10.Food allergenÀÇ Æ¯¼º---soluble, protein, IgE binding site, allergenecity, peptic/tryptic resistant 11.allergy ¿¬±¸---animal model, cell culture, similarity comparison, serum reaction 12. genetic modofication¿¡ ÀÇÇÑ GM food °³¹ß---³»¼º Áõ°¡ È¿°ú(º´ÃæÇØ, Á¦ÃÊÁ¦), nutrition ¼ººÐ º¯È(¸À, ¼ººÐ, Å©±â) storage(¹«¸£Áö ¾Ê´Â Å丶Åä) 13.°ËÃâ ¹æ¹ý---PCR, western blotting 14. substantial equivalence 15. serum bank 16.Maldi 1/Bet v1---»óµ¿¼º ¾à 60% CP4EPSPS/Derf2----30.5% ÀÏÄ¡,,,, ÀÏ·ÃÀÇ AA sequence°¡ 8°³ ÀÌ»óÀÌ¸é °¡´É¼º ³ôÀ½ 17. ½ºÅ¸¸µÅ©---Cry9c 18. ½ÄÇ° ¾Ë·¯Áö·Î¼ÀÇ ¹ß»ý°¡´É¼º= YES ¹ß»ý Áõ°Å= NO (Not yet) |