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ÀϹݻýÈÇÐ Áß°£½ÃÇè (15. 1Çбâ) Çаú(ºÎ): Çйø: À̸§: ¾ÏÈ£: ´ÙÀ½ÀÇ ¹è¿î ³»¿ë¿¡ ´ëÇÏ¿© ÀÚ¼¼È÷ ¼³¸íÇϽÿÀ. °¢ Áú¹®¿¡ ´ëÇÏ¿© °¡Àå Á¤È®ÇÑ ´äº¯À» 100%·Î ÇÏ¿© »ó´ëÀûÀ¸·Î äÁ¡ÇÕ´Ï´Ù. (1) Saccharomyces cerevisiae (yeast)¿¡¼ ¹ßÇöÇÏ´Â heat shock protein (HSP-70)Àº ºÐÀÚ·®ÀÌ 70 kDa Á¤µµÀÌ´Ù. ¨ç´Ü¹éÁú Á¤Á¦¹æ¹ý(4°¡Áö)¿¡ ÀÇ°ÅÇÏ¿© ÀÌ ´Ü¹éÁúÀÇ Á¤Á¦°úÁ¤À» ¼³¸íÇϽÿÀ (25Á¡). ¨èHSP-70ÀÇ ¾Ë·ÁÁöÁö ¾ÊÀº isozymeÀ» 2-D electrophoresis¿Í matrix-assisted laser desorption-ionization (MALDI)-TOF (Time Of Fly)·Î »õ·ÎÀÌ È®ÀÎÇÏ·Á°í ÇÑ´Ù. Àü °úÁ¤À» ±×¸²À» ±×·Á ÀÚ¼¼ÇÏ°Ô ¼³¸íÇϽÿÀ(25Á¡). (2) ´Ü¹éÁúÀÇ 1-4Â÷±¸Á¶¿¡ ´ëÇÏ¿© ¼³¸íÇϽÿÀ (´Ü, ¼³¸í¹®¿¡ ´ÙÀ½ÀÇ ´Ü¾î¸¦ ¹Ýµå½Ã Æ÷ÇÔ½ÃÅ°°í À̸¦ ¾Ë¾Æº¼ ¼ö ÀÖµµ·Ï Ç¥½ÃÇÏ¿© ¼³¸íÇϽÿÀ) (50Á¡). ¨çpeptide ±¸Á¶, ¨èalpha-helix, ¨ébeta-sheet, ¨êdisulfide bond, ¨ëdimer, tetramer, ¨ìbeta-turn ¶Ç´Â glycine, proline, asprtic acid, ¨íx-ray crystalography, ¨îmodification, ¨ïmad cow disease, ¨ðsignaling |