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“ 2008년도 2학기 생화학2 기말고사 시험문제 ”
Write the best answer to each question. (5 points) (1) ( ) is a readily mobilized storage form of glucose. It is a very large, branched polymer of glucose residues that can be broken down to yield glucose molecules when energy is needed. (2) Like the citric acid cycle, ( ) can continue only if NAD+ and FAD are regenerated. Hence, the rate of fatty acid degradation also is coupled to the need for ATP. Malonyl CoA, the precursor for fatty acid synthesis, inhibits fatty acid degradation by inhibiting the formation of acyl carnitine acyltransferase I, thus preventing the translocation of fatty acids into mitochondria. (3) ( ), a 20:4 fatty acid derived from linoleate, is the major precursor of several classes of signal molecule: prostaglandins, prostacyclins, thromboxanes, and leukotrienes. (4) Fatty acid synthesis starts with the carboxylation of acetyl CoA to malonyl CoA. This irreversible reaction is the committed step in fatty acid synthesis. The synthesis of malonyl CoA is catalyzed by ( ), which contains a biotin prosthetic group. (5) If ubiquitin is the mark of death, what is the executioner? A large protease complex called ( ) digests the ubiquitinated proteins. This ATP-driven multisubunit protease spares ubiquitin, which is then recycled. 아래를 자세하게 설명하시오. (15점) (6) Palmitate 1분자가 완전 산화되면 몇 분자의 ATP가 생성되는지 설명하시오. (7) Unsaturated and odd-chain fatty acid(불포화 홀수탄소의 지방산)의 산화에는 어떤 특정의 효소가 작용하는지 설명하여 보시오. (8) Urea cycle의 생체 내의 중요성에 대하여 설명하시오. 아래를 설명하되 반드시 그림을 그려서 설명하시오. (30점) (9) 당뇨 환자의 경우에 일어날 수 있는 metabolic pathway를 설명하되 다음의 지시에 합당하는 답을 적으시오. a) insulin이 분비되지 않아서 glucose 대사가 방해된다고 가정한다면 체내의 영양분은 어떻게 분해되어 생체에너지로 이용하는지 설명하시오. b) allosteric interaction, covalent modification, enzyme level의 조정, compartmentation의 단어를 사용하여 설명하시오. |
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